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Publications

Structural pharmacology and therapeutic potential of 5-methoxytryptamines

Nature 2024

Audrey L. Warren, David Lankri, Michael J. Cunningham, Inis C. Serrano, Lyonna F. Parise, Andrew C. Kruegel, Priscilla Duggan, Gregory Zilberg, Michael J. Capper, Vaclav Havel, Scott J. Russo, Dalibor Sames & Daniel Wacker

Molecular Design of SERTlight: A Fluorescent Serotonin Probe for Neuronal Labeling in the Brain

J Am Chem Soc 2024

Wei-Li Lee, Xavier Westergaard, Christopher Hwu, Jennifer Hwu, Tomas Fiala, Clay Lacefield, Umed Boltaev, Adriana M. Mendieta, Lisa Lin, Mark S. Sonders, Keaon R. Brown, Keer He, Wesley B. Asher, Jonathan A. Javitch, David Sulzer, and Dalibor Sames

2024

Dopamine transporter and synaptic vesicle sorting defects underlie auxilin-associated Parkinson's Disease

Cell Reports 2023

D.J. Vidyadhara, Mahalakshmi Somayaji, Nigel Wade, Betül Yücel, Helen Zhao, N. Shashaank, Joseph Ribaudo, Jyoti Gupta, TuKiet T. Lam, Dalibor Sames, Lois E. Greene, David L. Sulzer, Sreeganga S. Chandra

2023

Pharmacological Mechanism of the Non-hallucinogenic 5-HT2A Agonist Ariadne and Analogs

ACS Chem. Neurosci. 2022

Michael J. Cunningham#, Hailey A. Bock#, Inis C. Serrano#, Benjamin Bechand, D. J. Vidyadhara, Emma M. Bonniwell, David Lankri, Priscilla Duggan, Antonina L. Nazarova, Andrew B. Cao, Maggie M. Calkins, Prashant Khirsariya, Christopher Hwu, Vsevolod Katritch, Sreeganga S. Chandra, John D. McCorvy*, and Dalibor Sames*

Chemical Targeting of Rhodol Voltage-Sensitive Dyes to Dopaminergic Neurons.

ACS Chem. Neurosci. 2022

Tomas Fiala, Eugene V. Mosharov, Jihang Wang, Adriana M. Mendieta, Se Joon Choi, Eva Fialova, Christopher Hwu, David Sulzer, and Dalibor Sames

2022

A Novel Mitragynine Analog with Low-Efficacy Mu Opioid Receptor Agonism Displays Antinociception with Attenuated Adverse Effects.

J. Med. Chem. 2021

Soumen Chakraborty, Jeffrey F. DiBerto, Abdelfattah Faouzi, Sarah M. Bernhard, Anna M. Gutridge, Steven Ramsey, Yuchen Zhou, Davide Provasi, Nitin Nuthikattu, Rahul Jilakara, Melissa N. F. Nelson, Wesley B. Asher, Shainnel O. Eans, Lisa L. Wilson, Satyanarayana M. Chintala, Marta Filizola, Richard M. van Rijn, Elyssa B. Margolis, Bryan L. Roth, Jay P. McLaughlin, Tao Che, Dalibor Sames, Jonathan A. Javitch, and Susruta Majumda.

Oxidative Metabolism as a Modulator of Kratom's Biological Actions.

J. Med. Chem.. 2021

Soumen Chakraborty, Rajendra Uprety, Samuel T. Slocum, Takeshi Irie, Valerie Le Rouzic, Xiaohai Li, Lisa L. Wilson, Brittany Scouller, Amy F. Alder, Andrew C. Kruegel, Michael Ansonoff, Andras Varadi, Shainnel O. Eans, Amanda Hunkele, Abdullah Allaoa, Sanjay Kalra, Jin Xu, Ying Xian Pan, John Pintar, Bronwyn M. Kivell, Gavril W. Pasternak, Michael D. Cameron, Jay P. McLaughlin, Dalibor Sames, and Susruta Majumdar

Development of a Dual Fluorescent and Magnetic Resonance False Neurotransmitter That Reports Accumulation and Release from Dopaminergic Synaptic Vesicles.

ACS Chem. Neurosci. 2021

Michael R. Post, Wei-Li Lee, Jia Guo, Dalibor Sames, and David Sulzer

Novel Class of Psychedelic Iboga Alkaloids Disrupts Opioid Addiction States

BioRxiv. 2021

Vaclav Havel, Andrew C. Kruegel, Benjamin Bechand, Scot McIntosh, Leia Stallings, Alana Hodges, Madalee G. Wulf, Melissa Nelson, Amanda Hunkele, Mike Ansonoff, John E. Pintar, Christopher Hwu, Najah Abi-Gerges, Saheem A. Zaidi, Vsevolod Katritch, Mu Yang, Jonathan A. Javitch, Susruta Majumdar, Scott E. Hemby, Dalibor Sames.

Site selective C-H functionalization of Mitragyna alkaloids reveals a molecular switch for tuning opioid receptor signaling efficacy.

Nat. Commun. 2021

Srijita Bhowmik, Juraj Galeta, Vaclav Havel, Melissa Nelson, Abdelfattah Faouzi, Benjamin Bechand, Tomas Fiala, Amanda Hunkele, Andrew Kruegel, Susruta Majumdar, Jonathan A. Javitch, Dalibor Sames.

2021

Chemical Targeting of Voltage Sensitive Dyes to Specific Cells and Molecules in the Brain

J. Am. Chem. Soc. 2020

Tomas Fiala, Jihang Wang, Matthew Dunn, Peter Sebej, Se Joon Choi, Ekeoma C. Nwadibia, Eva Fialova, Diana M. Martinez, Claire E. Cheetham, Keri J. Fogle, Michael J. Palladino, Zachary Freyberg, David Sulzer, and Dalibor Sames.

A Single Administration of the Atypical Psychedelic Ibogaine or its Metabolite Noribogaine Induces an Antidepressant-like Effect in Rats

ACS Chem. Neurosci. 2020 

Paola Rodriguez, Jessika Urbanavicius, Jose Pedro Prieto, Sara Fabius, Ana Laura Reyes, Vaclav Havel, Dalibor Sames, Cecilia Scorza, and Ignacio Carrera.

2020

Chemical Targeting of Voltage Sensitive Dyes to Specific Cells and Molecules in the Brain

J. Am. Chem. Soc. 2020

Tomas Fiala, Jihang Wang, Matthew Dunn, Peter Sebej, Se Joon Choi, Ekeoma C. Nwadibia, Eva Fialova, Diana M. Martinez, Claire E. Cheetham, Keri J. Fogle, Michael J. Palladino, Zachary Freyberg, David Sulzer, and Dalibor Sames.

A Single Administration of the Atypical Psychedelic Ibogaine or its Metabolite Noribogaine Induces an Antidepressant-like Effect in Rats

ACS Chem. Neurosci. 2020 

Paola Rodriguez, Jessika Urbanavicius, Jose Pedro Prieto, Sara Fabius, Ana Laura Reyes, Vaclav Havel, Dalibor Sames, Cecilia Scorza, and Ignacio Carrera.

2019

Evoked transients of pH-sensitive fluorescent false neurotransmitter reveal dopamine hot spots in the globus pallidus

eLife 2018

Jozsef Meszaros, Timothy Cheung, Maya M Erler, Un Jung Kang, Dalibor Sames, Christoph Kellendonk, and David Sulzer

Designing a norepinephrine optical tracer for imaging individual noradrenergic synapses and their activity in vivo

Nature Communications 2018

Tomas Fiala, Jihang Wang, Matthew Dunn, Peter Sebej, Se Joon Choi, Ekeoma C. Nwadibia, Eva Fialova, Diana M. Martinez, Claire E. Cheetham, Keri J. Fogle, Michael J. Palladino, Zachary Freyberg, David Sulzer, and Dalibor Sames.
 

Toward Serotonin Fluorescent False Neurotransmitters: Development of Fluorescent Dual Serotonin and Vesicular Monoamine Transporter Substrates for Visualizing Serotonin Neurons

ACS Chem. Neurosci. 2018

Adam Henke, Yekaterina Kovalyova, Matthew Dunn, Dominik Dreier, Niko G. Gubernator, Iva Dincheva, Christopher Hwu, Peter Sebej, Mark S. Ansorge, David Sulzer, and Dalibor Sames

Identification of Fluorescent Small Molecule Compounds for Synaptic Labeling by Image-Based, High-Content Screening

ACS Chem. Neurosci. 2018

Matthew Dunn, Umed Boltaev, Anne Beskow, Sergey Pampou, Ronald Realubit, Torcato Meira, Joao Vaz Silva, Rose Reeb, Charles Karan, Steffen Jockusch, David Sulzer, Young Tae Chang, Dalibor Sames, and Clarissa L. Waites

2018

Multiplex quantitative assays indicate a need for reevaluating reported small-molecule TrkB agonists

Science Signaling 2017

Umed Boltaev, Yves Meyer, Farangis Tolibzoda, Teresa Jacques, Madalee Gassaway, Qihong Xu, Florence Wagner, Yan-Ling Zhang, Michelle Palmer, Edward Holson, and Dalibor Sames

Neuronal Depolarization Drives Increased Dopamine Synaptic Vesicle Loading via VGLUT

Neuron 2017

Jenny I. Aguilar, Matthew Dunn, Susana Mingote, Caline S. Karam, Zachary J. Farino, Mark S. Sonders, Se Joon Choi, Anna Grygoruk, Yuchao Zhang, Carolina Cela, Ben Jiwon Choi, Jorge Flores, Robin J. Freyberg, Brian D. McCabe, Eugene V. Mosharov, David E. Krantz, Jonathan A. Javitch, David Sulzer, Dalibor Sames, Stephen Rayport, and Zachary Freyberg

The Behavioral Effects of the Antidepressant Tianeptine Require the Mu-Opioid Receptor

Neuropsychopharmacology 2017

Benjamin Adam Samuels, Katherine M Nautiyal, Andrew C Kruegel, Marjorie R Levinstein, Valerie M Magalong, Madalee M Gassaway, Steven G Grinnell, Jaena Han, Michael A Ansonoff, John E Pintar, Jonathan A Javitch, Dalibor Sames, and Rene Hen

2017

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