Publications
Molecular Design of SERTlight: A Fluorescent Serotonin Probe for Neuronal Labeling in the Brain
J Am Chem Soc 2024
Wei-Li Lee, Xavier Westergaard, Christopher Hwu, Jennifer Hwu, Tomas Fiala, Clay Lacefield, Umed Boltaev, Adriana M. Mendieta, Lisa Lin, Mark S. Sonders, Keaon R. Brown, Keer He, Wesley B. Asher, Jonathan A. Javitch, David Sulzer, and Dalibor Sames
2024
Dopamine transporter and synaptic vesicle sorting defects underlie auxilin-associated Parkinson's Disease
Cell Reports 2023
D.J. Vidyadhara, Mahalakshmi Somayaji, Nigel Wade, Betül Yücel, Helen Zhao, N. Shashaank, Joseph Ribaudo, Jyoti Gupta, TuKiet T. Lam, Dalibor Sames, Lois E. Greene, David L. Sulzer, Sreeganga S. Chandra
2023
Pharmacological Mechanism of the Non-hallucinogenic 5-HT2A Agonist Ariadne and Analogs
ACS Chem. Neurosci. 2022
Michael J. Cunningham#, Hailey A. Bock#, Inis C. Serrano#, Benjamin Bechand, D. J. Vidyadhara, Emma M. Bonniwell, David Lankri, Priscilla Duggan, Antonina L. Nazarova, Andrew B. Cao, Maggie M. Calkins, Prashant Khirsariya, Christopher Hwu, Vsevolod Katritch, Sreeganga S. Chandra, John D. McCorvy*, and Dalibor Sames*
2022
A Novel Mitragynine Analog with Low-Efficacy Mu Opioid Receptor Agonism Displays Antinociception with Attenuated Adverse Effects.
J. Med. Chem. 2021
Soumen Chakraborty, Jeffrey F. DiBerto, Abdelfattah Faouzi, Sarah M. Bernhard, Anna M. Gutridge, Steven Ramsey, Yuchen Zhou, Davide Provasi, Nitin Nuthikattu, Rahul Jilakara, Melissa N. F. Nelson, Wesley B. Asher, Shainnel O. Eans, Lisa L. Wilson, Satyanarayana M. Chintala, Marta Filizola, Richard M. van Rijn, Elyssa B. Margolis, Bryan L. Roth, Jay P. McLaughlin, Tao Che, Dalibor Sames, Jonathan A. Javitch, and Susruta Majumda.
Oxidative Metabolism as a Modulator of Kratom's Biological Actions.
J. Med. Chem.. 2021
Soumen Chakraborty, Rajendra Uprety, Samuel T. Slocum, Takeshi Irie, Valerie Le Rouzic, Xiaohai Li, Lisa L. Wilson, Brittany Scouller, Amy F. Alder, Andrew C. Kruegel, Michael Ansonoff, Andras Varadi, Shainnel O. Eans, Amanda Hunkele, Abdullah Allaoa, Sanjay Kalra, Jin Xu, Ying Xian Pan, John Pintar, Bronwyn M. Kivell, Gavril W. Pasternak, Michael D. Cameron, Jay P. McLaughlin, Dalibor Sames, and Susruta Majumdar
Novel Class of Psychedelic Iboga Alkaloids Disrupts Opioid Addiction States
BioRxiv. 2021
Vaclav Havel, Andrew C. Kruegel, Benjamin Bechand, Scot McIntosh, Leia Stallings, Alana Hodges, Madalee G. Wulf, Melissa Nelson, Amanda Hunkele, Mike Ansonoff, John E. Pintar, Christopher Hwu, Najah Abi-Gerges, Saheem A. Zaidi, Vsevolod Katritch, Mu Yang, Jonathan A. Javitch, Susruta Majumdar, Scott E. Hemby, Dalibor Sames.
Site selective C-H functionalization of Mitragyna alkaloids reveals a molecular switch for tuning opioid receptor signaling efficacy.
Nat. Commun. 2021
Srijita Bhowmik, Juraj Galeta, Vaclav Havel, Melissa Nelson, Abdelfattah Faouzi, Benjamin Bechand, Tomas Fiala, Amanda Hunkele, Andrew Kruegel, Susruta Majumdar, Jonathan A. Javitch, Dalibor Sames.
2021
Chemical Targeting of Voltage Sensitive Dyes to Specific Cells and Molecules in the Brain
J. Am. Chem. Soc. 2020
Tomas Fiala, Jihang Wang, Matthew Dunn, Peter Sebej, Se Joon Choi, Ekeoma C. Nwadibia, Eva Fialova, Diana M. Martinez, Claire E. Cheetham, Keri J. Fogle, Michael J. Palladino, Zachary Freyberg, David Sulzer, and Dalibor Sames.
A Single Administration of the Atypical Psychedelic Ibogaine or its Metabolite Noribogaine Induces an Antidepressant-like Effect in Rats
ACS Chem. Neurosci. 2020
Paola Rodriguez, Jessika Urbanavicius, Jose Pedro Prieto, Sara Fabius, Ana Laura Reyes, Vaclav Havel, Dalibor Sames, Cecilia Scorza, and Ignacio Carrera.
2020
Chemical Targeting of Voltage Sensitive Dyes to Specific Cells and Molecules in the Brain
J. Am. Chem. Soc. 2020
Tomas Fiala, Jihang Wang, Matthew Dunn, Peter Sebej, Se Joon Choi, Ekeoma C. Nwadibia, Eva Fialova, Diana M. Martinez, Claire E. Cheetham, Keri J. Fogle, Michael J. Palladino, Zachary Freyberg, David Sulzer, and Dalibor Sames.
A Single Administration of the Atypical Psychedelic Ibogaine or its Metabolite Noribogaine Induces an Antidepressant-like Effect in Rats
ACS Chem. Neurosci. 2020
Paola Rodriguez, Jessika Urbanavicius, Jose Pedro Prieto, Sara Fabius, Ana Laura Reyes, Vaclav Havel, Dalibor Sames, Cecilia Scorza, and Ignacio Carrera.
2019
Designing a norepinephrine optical tracer for imaging individual noradrenergic synapses and their activity in vivo
Nature Communications 2018
Tomas Fiala, Jihang Wang, Matthew Dunn, Peter Sebej, Se Joon Choi, Ekeoma C. Nwadibia, Eva Fialova, Diana M. Martinez, Claire E. Cheetham, Keri J. Fogle, Michael J. Palladino, Zachary Freyberg, David Sulzer, and Dalibor Sames.
Toward Serotonin Fluorescent False Neurotransmitters: Development of Fluorescent Dual Serotonin and Vesicular Monoamine Transporter Substrates for Visualizing Serotonin Neurons
ACS Chem. Neurosci. 2018
Adam Henke, Yekaterina Kovalyova, Matthew Dunn, Dominik Dreier, Niko G. Gubernator, Iva Dincheva, Christopher Hwu, Peter Sebej, Mark S. Ansorge, David Sulzer, and Dalibor Sames
Identification of Fluorescent Small Molecule Compounds for Synaptic Labeling by Image-Based, High-Content Screening
ACS Chem. Neurosci. 2018
Matthew Dunn, Umed Boltaev, Anne Beskow, Sergey Pampou, Ronald Realubit, Torcato Meira, Joao Vaz Silva, Rose Reeb, Charles Karan, Steffen Jockusch, David Sulzer, Young Tae Chang, Dalibor Sames, and Clarissa L. Waites
2018
Neuronal Depolarization Drives Increased Dopamine Synaptic Vesicle Loading via VGLUT
Neuron 2017
Jenny I. Aguilar, Matthew Dunn, Susana Mingote, Caline S. Karam, Zachary J. Farino, Mark S. Sonders, Se Joon Choi, Anna Grygoruk, Yuchao Zhang, Carolina Cela, Ben Jiwon Choi, Jorge Flores, Robin J. Freyberg, Brian D. McCabe, Eugene V. Mosharov, David E. Krantz, Jonathan A. Javitch, David Sulzer, Dalibor Sames, Stephen Rayport, and Zachary Freyberg
The Behavioral Effects of the Antidepressant Tianeptine Require the Mu-Opioid Receptor
Neuropsychopharmacology 2017
Benjamin Adam Samuels, Katherine M Nautiyal, Andrew C Kruegel, Marjorie R Levinstein, Valerie M Magalong, Madalee M Gassaway, Steven G Grinnell, Jaena Han, Michael A Ansonoff, John E Pintar, Jonathan A Javitch, Dalibor Sames, and Rene Hen